Pese as contradições, naturais duma pandemia, há drogas úteis com contra indicações.

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Which Covid-19 drugs work best?

The first medical reports are in, but there’s no silver bullet for coronavirus infection yet.

by Antonio RegaladoMar 23, 2020

a fonte das informações

Results are in from the first organized trials of drugs to treat Covid-19, but so far, there’s no cure.

As the new respiratory disease spread widely starting in January, doctors—first in China and then in the US, Italy, and France—all moved to test readily available drugs that are used for other purposes and are fairly safe. Now, just three months into the pandemic, the first medical results from organized trials—studies structured to measure whether a drug actually helps—are becoming public. We count three so far, all involving drugs with antiviral properties.

Patients who end up in the ICU are begging for whatever treatment they can get, and demand for drugs will skyrocket in the US. Not only is the number of confirmed cases now over 35,000, but this week twice that many or more will likely feel the onset of typical symptoms like cough, fever, and shortness of breath.

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So far, there is no approved medicines for Covid-19, so the main treatment for severe cases isn’t drugs at all—it’s oxygen therapy, ventilators that help people breathe, and supportive care. Some patients get standard antibiotics.

Overall, scores of drug studies are under way, checking the benefits of everything from vitamin C to Chinese traditional medicine. A list of trials compiled by CellTrials.org, a consultancy, found that doctors had registered over 250 Covid-19 studies, mostly in China, and were seeking to recruit 26,000 patients. It may be another month before some other large, important studies, like several involving the experimental antiviral remdesivir, made by the US company Gilead, are ready to report any findings.

Here are the facts about the drug studies published so far.

Chloroquine or hydroxychloroquine

The hype: President Donald Trump praised the malaria drug, saying it had shown “tremendous promise” against Covid-19. “I think it’s going to be very exciting,” he said. “I think it could be a game-changer, and maybe not.”

HYDROXYCHLOROQUINE & AZITHROMYCIN, taken together, have a real chance to be one of the biggest game changers in the history of medicine. The FDA has moved mountains – Thank You! Hopefully they will BOTH (H works better with A, International Journal of Antimicrobial Agents)…..— Donald J. Trump (@realDonaldTrump) March 21, 2020

The report: Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an openlabel non-randomized clinical trial

The data: During early March, French doctors at IHU-Méditerranée Infection in Marseille, France, treated Covid-19 patients with hydroxychloroquine, a version of the 90-year-old malaria drug chloroquine. They tried giving 200 milligrams of hydroxychloroquine three times per day, over 10 days, to 26 patients, and some got the antibiotic azithromycin, too. In their report, treated patients had less virus in their system after six days than other patients at a different center, who didn’t get the treatment. The study’s conclusions aren’t firm because so few patients were involved and the study was not rigorously designed, although chloroquine has also been tried in China with rumors of success.

So does the drug work? Scientists say there’s not enough evidence to say. “Anecdotal reports may be true, but they are anecdotal,” Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, said during a briefing at the White House. “It was not done in a controlled clinical trial. So you really can’t make any definitive statement about it.”

In the absence of other options, Governor Andrew Cuomo of New York said his state, now a global epicenter of Covid-19, had obtained 70,000 doses of hydroxychloroquine and 750,000 doses of chloroquine, as well as azithromycin (also called Zithromax). “The trial will start this Tuesday,” said Cuomo over the weekend. “There is a good basis to believe they could work. The president ordered the FDA to move and the FDA moved.”

Chloroquine has risks, because it can affect heart rhythm. No one should take it without a prescription.

Favipiravir

The hype: News reports last week claimed Chinese officials had touted this antiviral medicine made in Japan as “clearly effective.”

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